Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

鉴定出 Pik3ca 突变是前列腺癌的遗传驱动因素，其与 Pten 缺失协同作用，加速前列腺癌进展和去势抵抗性生长

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作者：Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J

期刊：	Cancer Discovery	影响因子：	29.700
时间：	2018	起止号：	2018 Jun;8(6):764-779.
doi：	10.1158/2159-8290.CD-17-0867	研究方向：	肿瘤
疾病类型：	前列腺癌

Significance

We show PIK3CA mutation correlates with poor prostate cancer prognosis and causes prostate cancer in mice. Moreover, PIK3CA mutation and PTEN loss coexist in prostate cancer and can cooperate in vivo to accelerate tumorigenesis and facilitate CRPC. Delineating this synergistic relationship may present new therapeutic/prognostic approaches to overcome castration/PI3K-AKT-mTORC1/2 inhibitor resistance. Cancer Discov; 8(6); 764-79. ©2018 AACR.See related commentary by Triscott and Rubin, p. 682This article is highlighted in the In This Issue feature, p. 663.

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