Abstract
This study describes a 64-year-old female with a history of hepatitis C and cryoglobulinemia, who presented with respiratory symptoms, including dry cough, shortness of breath, and fever, alongside joint pain and fatigue. Initial workup revealed interstitial pneumonia, supported by chest imaging, and the patient was treated for pneumonia with standard antibiotic therapy. Despite no renal involvement, a hallmark of cryoglobulinemia, further testing confirmed elevated serum cryoglobulin levels. The patient was diagnosed with cryoglobulinemia complicated by pneumonia, a rare but significant manifestation of this disorder. Treatment was initiated with corticosteroids and immunosuppressive therapy. Cryoglobulinemia typically presents with renal complications, such as membranoproliferative glomerulonephritis, but this case highlights an atypical involvement of pulmonary pathology and arthritis without renal dysfunction. The patient responded well to therapy and was discharged with outpatient follow-up. This report underscores the importance of considering cryoglobulinemia in the differential diagnosis of patients with vasculitis symptoms, even when renal manifestations are absent. Additionally, it highlights the limited documentation of the association between cryoglobulinemia and pulmonary complications. Noting this association is crucial so that a clearer pattern can be established if more cases arise.