Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
鞘氨醇通过干扰线粒体功能参与 PAPTP 诱导的胰腺癌细胞死亡
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作者：Sameer H Patel, Gregory C Wilson, Yuqing Wu, Simone Keitsch, Barbara Wilker, Andrea Mattarei, Syed A Ahmad, Ildiko Szabo, Erich Gulbins
Key messages
Pancreatic ductal adenocarcinoma (PDAC) is a common tumor with poor prognosis. The mitochondrial Kv1.3 ion channel blocker induced mitochondrial sphingosine. Sphingosine binds to cardiolipin thereby mediating mitochondrial depolarization. Sphingosine is formed by a PAPTP-mediated activation of S1P-Phosphatase. Inhibition of sphingosine-consumption amplifies PAPTP effects on PDAC in vivo.
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