RETRACTED: KYA1797K down-regulates PD-L1 in colon cancer stem cells to block immune evasion by suppressing the β-catenin/STT3 signaling pathway

撤回:KYA1797K 通过抑制 β-catenin/STT3 信号通路下调结肠癌干细胞中的 PD-L1,从而阻止免疫逃避

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作者:Zhiyan Ruan, Minhua Liang, Manxiang Lai, Ling Shang, Xiangliang Deng, Xinguo Su

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figures 2B,C,D+E and 3A,B,C,F+G, and a suspected image duplication within Figure 1B, as they appeared to feature in previous publications, as detailed here: https://pubpeer.com/publications/DCF33B20702DC3AE0C9D750A90174B; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The journal requested the corresponding author comment on these concerns and to provide the raw data. The corresponding author, Xinguo Su, stated “…the researchers responsible for technical support and data storage have left due to the impact of the epidemic, and along with much of the data involved in the paper”. The editorial team were not convinced that the raw Western blot data that was shared represented uncropped and unadjusted source data, so its veracity could not be adequately confirmed. The Editor-in-Chief decided to retract the article.

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