Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer

雄激素受体的强效刺激引发前列腺癌的病毒模拟反应

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作者:Mohammadreza Alizadeh-Ghodsi, Katie L Owen, Scott L Townley, Damien Zanker, Samuel P G Rollin, Adrienne R Hanson, Raj Shrestha, John Toubia, Tessa Gargett, Igor Chernukhin, Jennii Luu, Karla J Cowley, Ashlee Clark, Jason S Carroll, Kaylene J Simpson, Jean M Winter, Mitchell G Lawrence, Lisa M Butler

Significance

Our study demonstrates that potent androgen stimulation of prostate cancer cells can elicit a viral mimicry response, resulting in enhanced IFN signaling. This finding may have implications for the development of strategies to sensitize prostate cancer to immunotherapies.

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