Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy

意大利中部市政污水中分离的维罗尼气单胞菌和嗜水气单胞菌中新型天然CphA金属β-内酰胺酶CphA4和CphA5的鉴定

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作者：Bottoni,Carlo,Marcoccia,Francesca,Compagnoni,Chiara,Colapietro,Martina,Sabatini,Alessia,Celenza,Giuseppe,Segatore,Bernardetta,Maturo,Maria Giovanna,Amicosante,Gianfranco,Perilli,Mariagrazia
期刊：Antimicrobial Agents and Chemotherapy影响因子：4.500
时间：2015起止号：2015 Aug;59(8):4990-3
doi：10.1128/AAC.00628-15

Abstract

Two new natural CphA metallo-β-lactamases, the CphA4 and CphA5 enzymes, were identified in water samples from municipal sewage in central Italy. Compared to CphA, the CphA4 and CphA5 enzymes showed numerous point mutations. These enzymes have a narrow spectrum of substrates focused on carbapenems only. CphA5 showed kcat values about 40-, 12-, and 97-fold higher than those observed for CphA4 versus imipenem, ertapenem, and biapenem, respectively.

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