High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity

细胞外 ATP 水平高导致 COVID-19 患者根据病情严重程度出现不同的炎症反应

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作者：Gilnei Bruno da Silva #, Daiane Manica #, Alana Patrícia da Silva, Greicy Cristine Kosvoski, Marceli Hanauer, Charles Elias Assmann, Júlia Leão Batista Simões, Micheli Mainardi Pillat, Jéssica Dotto de Lara, Filomena Marafon, Amanda Gollo Bertollo, Maiqueli E D Mingoti, Jullye Gavioli, Gislaine Zill

期刊：

Journal of Molecular Medicine-Jmm

影响因子：

时间：

2022

起止号：

2022 Apr;100(4):645-663.

doi：

10.1007/s00109-022-02185-4

研究方向：

代谢、免疫、心血管

疾病类型：

新冠

细胞类型：

其它细胞

Key messages

COVID-19 patients exhibit alterations in purinergic system and immune response. High levels of extracellular ATP lead to different inflammatory responses. CD39 and CD73 expression were increased in COVID-19 patients. Cytokines IL-2, IL-6, IL-10, and IL-17 also were altered in these patients. The purinergic system may be a possibility target to SARS-CoV-2 treatments.

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