Abstract
Gliomas are common primary brain tumors in the central nervous system, characterized by invasiveness, heterogeneity, and drug resistance, posing a threat to patients' lives. Glioblastoma (IDH wild-type) exhibits the highest invasiveness and mortality rate, making it a challenging therapeutic target. This review first outlines the characteristics of gliomas and their impact on the nervous system, then explores the pathological mechanisms and unique behaviors of glioblastoma (IDH wild-type), as well as the influence of the nervous system on its occurrence and progression. In terms of treatment, potential targeted strategies are summarized, and the potential of novel precision therapies, such as immunotherapy and gene therapy, is evaluated. This article underscores the importance of understanding the complex interactions between the nervous system and gliomas, offering new perspectives and targets for treatment. Future research should elucidate these interactions to identify more effective therapeutic targets and improve patient prognosis and quality of life.