Abstract
Chicken infectious anemia (CIA) is caused by the CIA virus (CIAV) and is a globally distributed immunosuppressive disease, resulting in substantial economic losses for the poultry industry. Vaccination is the most cost-effective and efficient strategy for preventing and controlling infectious diseases. The most common CIA vaccines used internationally are attenuated vaccines. Although inactivated vaccines, subunit vaccines, immune complex vaccines, recombinant live viral vector vaccines, and DNA vaccines used for preventing CIAV infection have been developed and exhibited relatively satisfactory immune responses, they have not yet achieved large-scale market applications. Therefore, accelerating the introduction of safe and effective CIA vaccines to the market and developing novel vaccines are crucial for the control of CIA in the poultry industry. This article reviews the etiological characteristics of CIAV, the epidemic features, and the research progress of CIA vaccines, and proposes future research directions, with the aim of providing innovative ideas and scientific references for the research and development of new, safe, and efficient CIA vaccines.