Abstract
It is evident the increase in the occurrence of different stresses that impact agriculture and so there has been an increase in research to study stress mitigators including silicon (Si) and selenium (Se). However, the great challenge to be answered would be to assess whether it is possible to maximize these benefits by combining these two elements. Therefore, this review focused on discussing the feasibility of combining Se and Si in mitigating abiotic stresses and also measuring gains in yield and quality of agricultural products. These are the main challenges of plant mineral nutrition with these two elements for sustainable cultivation, ensuring food security with the possibility of improving human health. As the mode of application of an element can change absorption and assimilation processes and consequently the plant's response, it is important to consider research with supply of these elements via the foliar and root route. Thus, we highlighted the potential of the combined application of Se and Si and whether or not they are relevant to overcome the individual application in stress mitigation or even in plants without stress. In addition, we pointed out new directions for research on this topic in order to reinforce the combined use of stress relievers and their potential benefit to crop plants.