Abstract
INTRODUCTION: Lymphoid leukemia is a major cause of death, and its link with septicemia is progressively studied. It is crucial to understand that the relationship is important for identifying high-risk populations and designing targeted public health interventions. AIMS: This study aims to evaluate mortality trends in lymphoid leukemia with septicemia as a contributing cause of death, using the CDC Multiple Causes of Death (MCD) database. METHODOLOGY: A study retrospectively examined data from the CDC MCD database to determine trends in deaths among individuals 25 years and older in the US from 1999 through 2020. They examined deaths with lymphoid leukemia as the underlying cause of death and septicemia as a contributing cause. The data were categorized by sex, race, geographic region, and location of death. Age-adjusted mortality rate (AAMR) and annual percentage change (APC) were calculated. RESULTS: From 1999 to 2020, 17,265 adults over 25 died with lymphoid leukemia and septicemia. Most deaths occurred in metropolitan areas (N = 14,267, 82.6%). Males (N = 10,825, 62.7%) and White individuals (N = 14,953, 86.6%) had the highest mortality. The crude death rate was 3.9 per million population. CONCLUSION: This study highlights significant mortality trends increasing in lymphoid leukemia with septicemia with disparities by gender and race. Findings underscore the need for targeted prevention strategies and improved healthcare access.