Abstract
Background/Objectives: Allergic contact dermatitis (ACD) is a chronic inflammatory disease with a high prevalence, affecting various aspects of patients' lives. Psychosocial factors may influence disease management and outcomes, including perceived stress, locus of control, and self-efficacy. This study examines the presence of these factors in ACD and their association with disease severity and patient characteristics. Methods: A cross-sectional study included 225 adults with ACD and 225 healthy controls. Exclusion criteria were other skin diseases, psychiatric disorders, or intellectual disabilities. Sociodemographic and clinical variables, such as disease duration and severity, were recorded. Perceived stress, locus of control, and self-efficacy were assessed using validated questionnaires. Statistical analyses, including t-tests and multiple linear regression, were performed to explore group differences and predictors of clinical and psychosocial outcomes. Results: ACD patients exhibited higher perceived stress than controls (M = 39.36 vs. 24.74, p < 0.001), with stress levels correlating with disease severity (B = 0.062, 95% CI [0.050, 0.074], p < 0.001). Female sex (B = -5.896, p < 0.001) and lower education (B = -2.606, p = 0.035) predicted higher stress. Locus of control and self-efficacy showed statistically significant but modest differences between groups. Conclusions: Perceived stress was significantly associated with the severity of ACD, highlighting the necessity of incorporating psychological interventions into disease management. Programs focused on stress reduction and patient education should be integrated into clinical care to enhance outcomes. Longitudinal research is essential to establish causal relationships and evaluate the long-term benefits of tailored psychological support on disease progression and patient well-being.