Abstract
INTRODUCTION AND IMPORTANCE: Sensitivity to medical adhesives, such as Leukoplast, can lead to significant skin reactions, complicating wound management. While systemic corticosteroids are the mainstay of treatment for severe adhesive hypersensitivity, the adjunctive role of moist wound dressings in optimizing local wound healing and patient comfort remains underexplored. CASE PRESENTATION: A 70-year-old woman with hyperthyroidism and hypertension developed blood blisters 4 h after leukoplast adhesive application during hospitalization for seizures. Referred to wound care, clinical assessment revealed dermal coagulation, inflammation, erythema, and peri-wound pain. Prior history included adhesive hypersensitivity with hives and pruritus. CLINICAL DISCUSSION: Following blister aspiration and debridement, hydrocolloid dressings were applied to sustain moisture, alongside systemic hydrocortisone, cefazolin, and nutritional support. Follow-up showed progressive healing without maceration, highlighting moisture retention's role in epithelialization. The TIME framework guided tissue, inflammation, and moisture management, emphasizing individualized care to avoid further adhesive exposure. CONCLUSION: This case underscores the effectiveness of moist wound dressings combined with pharmacological and nutritional interventions in managing adhesive sensitivity. Ensuring a moist wound environment is crucial for healing. This approach highlights the need for personalized wound care strategies to address adhesive sensitivities effectively.