Treatment of Refractory Grover's Disease With Dupilumab: A Case Study

使用度普利尤单抗治疗难治性格罗弗病:病例研究

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Abstract

Grover's disease (GD) is a pruritic skin condition characterized by erythematous, scaly papules on the trunk, often resolving spontaneously but sometimes becoming persistent and difficult to manage. In this case study, we discuss a 73-year-old male with treatment-resistant GD who experienced significant improvement with dupilumab injections. Within two weeks, the patient reported noticeable improvement in pruritus and rash, with complete resolution achieved after five months of continued treatment and no notable adverse effects. This case can highlight dupilumab as a promising option for refractory GD, as well as support the hypothesis of an immune-mediated pathogenesis of GD.

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