Abstract
BACKGROUND: Well-differentiated small bowel mesenteric liposarcoma (LPS) is rare, with high malignancy, poor prognosis, and high preponderance to local recurrence. CASE SUMMARY: Here we described a 71-year-old male, who complains of persistent abdominal distension for a month. The clinical manifestation is a huge abdominal mass occupying almost the entire abdomen. Physical examination indicated palpable massive mass in the abdomen, hard texture, indefinable boundary, poor mobility. The abdominal enhanced computed tomography at another hospital scan showed multiple abdominal masses originating from the small bowel mesentery. Abdominal and pelvic magnetic resonance imaging at our hospital showed multiple masses in the abdominal and pelvic cavities, indicating that the tumor originated from the mesentery or peritoneum. Results of exploratory laparotomy indicated that the tremendous mass primarily results from the mesentery of the small intestine, occupying the entire abdominal cavity in a polymorphic and lobulated shape. The patient underwent complete surgical resection of the tumor, and the weight of the tumor was approximately 11 kg. The histopathological examination of the resected specimens confirmed the diagnosis of well-differentiated LPS of the small bowel mesentery. CONCLUSION: Completed surgical resection was cornerstone, and histopathological and molecular confirmations were crucial. The necessity of adjuvant therapy should be phrased as a potential consideration to improve patient's survival time.