Human papillomavirus partial L2 gene variants in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence

High-risk human papillomavirus (HPV) genotypes 16 and 18 are associated with Barrett's dysplasia and esophageal adenocarcinoma. We sequenced 33 HPV partial L2 genes from Australian esophageal specimens. Phylogenetic analysis showed 32 were HPV-16 and one was HPV-18, underscoring the predominance and importance of HPV-16.