Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers
血清外泌体冠蛋白 1A 和动力蛋白 2 作为神经管缺陷生物标志物
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作者：Yanfu Wang #, Ling Ma #, Shanshan Jia, Dan Liu, Hui Gu, Xiaowei Wei, Wei Ma, Wenting Luo, Yuzuo Bai, Weilin Wang, Zhengwei Yuan
Key messages
We used proteomics to identify novel proteins specific for NTDs. CORO1A and DNM2 showed exosome-specific expression and were associated with SBA. CORO1A and DNM2 were downregulated in maternal serum exosomes and FNEs. CORO1A and DNM2 showed good diagnostic efficacy for NTDs during early gestation. These two targets may have applications as NTD screening and diagnostic biomarkers.
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