Abstract
Tissue-resident memory (T(RM)) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. T(RM)- like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. T(RM) cells have also been shown to mediate anti-tumor immunity in murine models. Biology of T(RM) cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of T(RM) T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.