Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms

全基因组表达谱分析揭示免疫功能在人类腹主动脉瘤中的重要作用

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Abstract

BACKGROUND: Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (AAA) and non-aneurysmal abdominal aorta, and identified genes that were significantly differentially expressed between cases and controls. RESULTS: Affymetrix and Illumina arrays included 18,057 genes in common; 11,542 (64%) of these genes were considered to be expressed in either aneurysmal or normal abdominal aorta. There were 3,274 differentially expressed genes with a false discovery rate (FDR)

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