Abstract
BACKGROUND: Numerous studies have observed risk factors for breast cancer. We investigated the association between quality life factors as breast cancer risks in a case-control study in industrial Zenica- Doboj Canton in Bosnia and Herzegovina. METHODS: The case-control study was included 200 women, 100 without (control subjects) and 100 women with diagnosed breast cancer. We used questionnaires about breast cancer risks" as study tool. Logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CI) and a full assessment of confounding was included in analysis. RESULTS: Breast cancer was positive associated with increasing age of life (from 45 years and more; OR= 1.25); further relative breast cancer history (OR= 4.42; 95%CI, 0.483-4.043); exposure to CT (OR=2.02; 95%CI, 1,254-3.261); never birth child (OR= 1.394; 95%CI, 0.808-2,407); used replacement hormonal therapy (OR= 1.826; 95%CI, 1.637-10.590); arrival time of menstruation (OR=2.651; 95%CI, 1.303-1.571); length of smoking status (OR=1.534; 95%CI, 0.756-3.098), alcohol consumption (OR=1.728; 95% CI, 0.396-7.533); exposure to CT per year (p=0.009), routine physical inactivity (p=0.009) and replacement hormones treatment (p=0.036). CONCLUSION: Inverse associations of breast cancer and poverty, arival time of menopause were observed. The link between breast cancer and a distant-cousin- degree family history of breast cancer was inverse association with breast cancer too. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer.