Abstract
INTRODUCTION: This study examines how an early-life small-quantity lipid-based nutrient supplement (LNS) interacts with the home environment to influence Ghanaian children's social-emotional functioning at preschool age. METHOD: In a randomized controlled trial, 1,320 Ghanaian women received either daily LNS, multiple micronutrients (MMN) or iron and folic acid (IFA) during pregnancy through 6 months postpartum. Infants in the LNS group received the daily supplement from 6 to 18 months. The IFA and MMN groups were combined to be the control group. At 4-6 years (n = 966), we assessed children's home environments (caregiver responsivity, negative behavior acceptance, physical environment, learning materials, academic stimulation) and their social-emotional strengths and difficulties. RESULTS: Both LNS and higher quality home environments-particularly caregiver responsivity and negative behavior acceptance-predicted children having fewer social-emotional difficulties. LNS supplementation moderated relations between the home environment and children's hyperactivity/inattention and total difficulties. Living in a safer physical environment was related to fewer hyperactivity/inattention problems and total difficulties only for children who received LNS. Less academic stimulation was related to more hyperactivity/inattention only for children in the control group. CONCLUSION: Early-life LNS supplementation and supportive home environments reduce social-emotional difficulties in Ghanaian children. Nutritional interventions are most effective in the context of safe, stimulating households, demonstrating that integrated interventions support children's wellbeing in low- and middle-income countries. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov; identifier: NCT00970866.