Abstract
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related mortality worldwide, responsible for approximately 900000 deaths annually. Inflammation and malnutrition significantly influence patients' responses to treatment. Markers such as serum albumin concentration, the prognostic nutritional index, nutritional risk index (NRI), geriatric NRI, and the systemic immune-inflammation index enable the early identification of high-risk patients, facilitating timely interventions that can improve survival and reduce morbidity. A comprehensive understanding and application of these markers allow for better risk stratification in CRC patients, optimizing their management and outcomes.