Abstract
Wound healing is a complex and finely regulated biological process involving a variety of cell types, such as immune cells, fibroblasts, keratinocytes, endothelial cells, and stem cells. In recent years, scientific research has unveiled the significant role of circadian rhythms in the regulation of wound healing process. Although the molecular mechanisms by which circadian rhythms precisely regulate wound healing are not yet fully understood, accumulating evidence has revealed that some key signals and cellular functions play crucial roles in the circadian rhythm regulation of wound healing. A deeper understanding of these mechanisms is important not only to uncover the basic biological processes of wound healing, but also to develop new therapeutic strategies, such as regulating circadian rhythms to guide medication and optimize trauma treatment. By reviewing the current research results on circadian rhythm regulation of wound healing, this paper aims to provide a comprehensive perspective on this emerging field and provide valuable insights for future research directions.