Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis

内皮 VEGFR 辅助受体神经纤毛蛋白-1 和神经纤毛蛋白-2 对肿瘤血管生成至关重要

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作者:Christopher J Benwell, Robert T Johnson, James A G E Taylor, Christopher A Price, Stephen D Robinson

Significance

The findings presented in this study demonstrate that tumor angiogenesis and growth can be arrested completely by cotargeting endothelial NRP1 and NRP2. We provide new insight into the mechanisms of action regulating NRP-dependent tumor angiogenesis and signpost a novel approach to halt tumor progression.

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