Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer

芥子汤通过Nrf2通路逆转肺癌顺铂耐药性

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作者:Jing Zhao, Manting Hou, Kaixin Ding, Shixiong Li, Hui Li, Xili Zhang, Zhaofang Bai, Wenlong Liu

Conclusions

Collectively, these results indicate that co-treatment with JGT and DDP can be considered a combinational approach to treating DDP resistance.

Methods

Cell viability was assessed using cell counting kit-8 assay. Flow cytometry was applied to detected cell apoptosis, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels. Western blotting and qRT-PCR were performed to determine protein and mRNA levels. Key findings: The

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