Abstract
Oxathiapiprolin was developed with high antifungal activity and novel target protein and is used in the oomycetes control for crop protection. The structural modifications of oxathiapiprolin are summarized. The achievements and challenges in the structural modification of oxathiapiprolin are also discussed in this mini review. The outlook in this field is perspected according to our own opinion and understanding on the development of oxysterol binding protein inhibition fungicides.