Abstract
This study mainly analyzed the EEG changes and the development of neurological impairment at different stages of the disease, and explored the clinical role of the Grand Total EEG score (GTE score) in evaluating the degree of neurological impairment function damage in anti-NMDA receptor encephalitis. The GTE scores of patients with anti-NMDA receptor encephalitis at different disease stages and the diagnostic validity of the GTE scores for evaluating the degree of neurological impairment were analyzed. 153 EEG cases were included in this study, with a course of 2 to 960 days. The abnormal EEG rates were 92% in the acute phase, 83% in the recovery phase, 76% in the short-term prognosis phase, and 30% in the long-term prognosis phase. The GTE score: acute phase=(5, 0-15); recovery phase=(2, 0-14); short-term prognosis phase= (2, 0-9); long-term prognosis phase = (0, 0-6). When the total GTE score is 5.5, the patient was more likely to have moderate to severe neurological impairment (mRS = 4), with sensitivity and specificity > 0.9. When the total GTE score was 7.5, the patient was more likely to have severe neurological impairment (mRS = 5), with sensitivity and specificity > 0.9. GTE score has a high diagnostic efficacy for the rating of neurological impairment. The total GTE score was superior to the assessment of neurological damage degree solely from background activity frequency or diffuse slow wave activity.