Natural Killer Cell Expansion with Autologous Feeder Layer and Anti-CD3 Antibody for Immune Cell Therapy of Hepatocellular Carcinoma

利用自体饲养层和抗 CD3 抗体进行自然杀伤细胞扩增,用于肝细胞癌的免疫细胞治疗

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作者:Faezeh Hosseinzadeh, Jafar Ai, Somayeh Ebrahimi-Barough, Iman Seyhoun, Abbas Hajifathali, Samad Muhammadnejad, Fatemeh Hosseinzadeh, Mahdi Shadnoush, Farnaz Dabiri Oskouei, Javad Verdi

Background

one of the promising approaches for treatment of some cancers is adoptive cell therapy using natural killer (NK) cells. Various

Conclusion

we proposed an effective method for expansion of cytotoxic NK cells using irradiated autologous PBMC as feeder layer for more successful transfer of allogeneic NK cell in immuno cell therapy of HCC.

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