Abstract
BACKGROUND AND AIM: Diabetic foot ulcers (DFUs) pose a significant challenge in the management of chronic wounds, characterized by a high risk of infection and severe complications, including potential limb amputation. The limitations of conventional treatments have sparked interest in regenerative therapies, particularly the use of adipose-derived stem cells (ADSCs). which possess significant potential across various medical fields for enhancing tissue repair and modulating immune responses. This perspective critically evaluates the potential of ADSCs for treating DFUs while exploring their broader implications in regenerative medicine. METHODS: This perspective incorporates insights from a comprehensive literature review, with searches conducted on platforms such as Google Scholar, PubMed, and Scopus. The selected studies focus on the regenerative efficacy, safety, and clinical applications of ADSCs in wound healing, emphasizing rigorous methodologies that support reliable conclusions. RESULTS: ADSCs exhibit significant promise in promoting tissue regeneration, stimulating angiogenesis, and modulating immune function-mechanisms that are beneficial not only for patients with DFUs but also for those with other chronic and non-healing wounds. Nevertheless, challenges persist, including the risk of tumorigenesis, particularly in patients with a history of cancer, as well as variability in therapeutic outcomes due to donor characteristics and processing techniques. CONCLUSION: While ADSCs represent a promising therapeutic option for DFUs and provide valuable insights for a wider array of chronic wound therapies, their clinical application requires careful consideration of safety concerns, including risks of tumor formation and immune response issues. Future advancements in cell processing and well-structured clinical trials will be essential to ensuring efficacy across diverse populations in the broader context of regenerative medicine.