Abstract
Chronic tendinopathy is a degenerative condition characterized by persistent pain, functional limitations, and tendon thickening, often resulting from repetitive overuse or failed tendon healing. Left untreated, it can progress to tendon rupture, prolonged disability, and impaired quality of life. Management typically includes conservative therapies, such as physical therapy, corticosteroid (CS) injections for short-term relief, and platelet-rich plasma (PRP) as a regenerative therapy with potential long-term benefits. This systematic review and meta-analysis evaluates and compares the effectiveness of PRP and CS injections for chronic tendinopathies regarding pain reduction, functional improvement, and long-term outcomes. A structured search of PubMed, Scopus, Google Scholar, and the Cochrane Library identified randomized controlled trials (RCTs) and comparative studies. Primary outcomes included pain reduction and functional improvement while secondary outcomes assessed heterogeneity and publication bias. PRP and CS injections demonstrated no significant difference in short-term pain reduction. Functional outcomes were comparable in the short term but showed a trend favoring PRP at longer follow-up periods. PRP exhibited a slight advantage in long-term functional recovery, though the results were not statistically significant. Substantial heterogeneity across studies highlights the need for standardized protocols and larger trials to confirm these findings and optimize treatment strategies.