Abstract
Plasmalogens, as natural dietary lipids, are a unique class of glycerophospholipids with distinct structural and functional properties. They are unstable due to the vinyl ether linkage and the unsaturated fatty chains. Hence, plasmalogen changes are closely connected to their beneficial bioactivities and health-related applications. This narrative review focuses on their structural modifications, particularly oxidation of the vinyl-ether and sn-2 acyl chains, enzymatic degradation, and molecular remodeling. The oxidative susceptibility of plasmalogens renders them particularly vulnerable under inflammatory or oxidative stress, contributing to a measurable reduction in total plasmalogen content. Plasmalogen deficiency has been observed in various diseases and applied in clinical applications, including physiological and a variety of pathological conditions. Moreover, plasmalogens have been recognized as not only disease biomarkers but also therapeutic targets. In addition, recent findings in nutrition were discussed, aiming to find that underutilized animal byproducts and microbial lipids are promising new sources of plasmalogens. To conclude, it is crucial to establish practical dynamic monitoring systems of plasmalogens for health promotion and disease prevention interventions. Integrating biochemical pathways, clinical diagnosis, and nutritional interventions remains to be clarified.