Abstract
E-cigarette use among adolescents is a growing public health concern, driven by discreet designs, appealing flavors, and social influences. Despite high addiction rates, most teen users express a desire to quit, though evidence-based cessation tools remain limited. Behavioral interventions, including tech-based programs like This Is Quitting and smokeSCREEN, show promise. Pharmacotherapy, particularly varenicline, may support quitting, though its role in adolescents is still under investigation. Pediatricians must address this issue through empathetic, multifaceted approaches that combine education, behavioral support, and emerging treatments to curb early nicotine dependence and its long-term health consequences.