Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

衰老成纤维细胞脂质代谢的变化通过脂肪酸转运蛋白 FATP2 诱导年龄依赖性黑色素瘤细胞对靶向治疗产生耐药性

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作者：Gretchen M Alicea, Vito W Rebecca, Aaron R Goldman, Mitchell E Fane, Stephen M Douglass, Reeti Behera, Marie R Webster, Curtis H Kugel 3rd, Brett L Ecker, M Cecilia Caino, Andrew V Kossenkov, Hsin-Yao Tang, Dennie T Frederick, Keith T Flaherty, Xiaowei Xu, Qin Liu, Dmitry I Gabrilovich, Meenhard Her

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2020

起止号：

2020 Sep;10(9):1282-1295.

doi：

10.1158/2159-8290.CD-20-0329

研究方向：

代谢、信号转导、肿瘤

疾病类型：

黑色素瘤

细胞类型：

成纤维细胞

信号通路：

Senescence

Significance

These data show that melanoma cells take up lipids from aged fibroblasts, via FATP2, and use them to resist targeted therapy. The response to targeted therapy is altered in aged individuals because of the influences of the aged microenvironment, and these data suggest FATP2 as a target to overcome resistance.See related commentary by Montal and White, p. 1255.This article is highlighted in the In This Issue feature, p. 1241.

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