Abstract
Down syndrome, also known as trisomy 21, is the most frequently identified chromosomal disorder. Patients with Down syndrome frequently present with a broad spectrum of dermatological conditions, including atopic dermatitis, nonspecific dermatitis, folliculitis, seborrheic dermatitis, and cutaneous infections. Several cases of generalized lichen nitidus in individuals with Down syndrome have been reported. However, dermoscopic findings have not been previously described in these cases. We report a case in which dermoscopy contributed significantly to the clinical diagnosis, illustrating its potential role in improving diagnostic accuracy.