Abstract
INTRODUCTION: Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD). AIM: To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD. MATERIAL AND METHODS: The study group consisted of 191 patients with AD and 168 controls. RESULTS: The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, p = 0.01). CONCLUSIONS: The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.