Leveraging preclinical study designs to close gaps in vaccine development for perinatal pathogens

利用临床前研究设计来弥补围产期病原体疫苗研发方面的差距

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Abstract

Vaccines to perinatal pathogens are critical for both reducing the burden of endemic pathogens and preparing for the next pandemic. Although they are often at greater risk of severe disease from infection, pregnant people and children are routinely marginalized in the vaccine development process. We highlight several challenges in the vaccine development process and how three tools-translational animal models, human cohort studies of natural infection, and innovative data-use strategies-can speed vaccine development and ensure equity for pregnant people and children in the next pandemic.

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