Effects of antimicrobial peptide revealed by simulations: translocation, pore formation, membrane corrugation and euler buckling

模拟揭示的抗菌肽效应:转位、孔隙形成、膜皱褶和欧拉屈曲

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Abstract

We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.

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