High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer
磷酸甘油酸脱氢酶高表达预示高级别浆液性卵巢癌患者预后不良
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作者：Lilian van Wagensveld, Tom Van Nyen, Daniela Annibali, Gabe S Sonke, Roy F P M Kruitwagen, Frederic Amant, Hugo M Horlings
| 期刊： | Oncologist | 影响因子： | 4.800 |
| 时间： | 2024 | 起止号： | 2024 Sep 6;29(9):e1231-e1234. |
| doi： | 10.1093/oncolo/oyae161 | 研究方向： | 肿瘤 |
| 疾病类型： | 卵巢癌 | |
Methods
Data from 306 patients with advanced-stage HGSOC treated between 2008 and 2015 were analyzed. PHGDH expression levels were determined using immunohistochemistry and categorized as "low" or "high."
Results
PHGDH-high was associated with higher FIGO stage and increased use of neoadjuvant chemotherapy. Patients with PHGDH-high tumors had significantly worse survival than PHDH-low, even after adjusting for confounding factors.
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