Abstract
The role of microRNA-107 (miR-107) as a tumor suppressor has been explored in different types of human cancer. However, the expression and role of miR-107 in oral squamous cell carcinoma (OSCC) remains elusive. Here, the expression of miR-107 in OSCC cell lines was explored by reverse transcription-quantitative polymerase chain reaction. Online prediction algorithms and luciferase activity reporter assay were conducted to validate the targets of miR-107. Cell counting kit-8 assay and wound-healing assay were performed to analyze the functions of miR-107 on OSCC cells. These results indicated that miR-107 had reduced expression in OSCC cells. Overexpression of miR-107 inhibits OSCC cell proliferation and migration. It was found that miR-107 directly targets TP53 regulated inhibitor of apoptosis 1 (TRIAP1) to regulate gene expression. Together, these results demonstrated that miR-107 also plays a tumor suppressive role by inhibiting proliferation and migration of OSCC cells by targeting TRIAP1. Our finding provides novel insights into the mechanism of OSCC progression.