Abstract
OBJECTIVE: To evaluate a series of vascular parameters derived from abdominal dual-phase contrast-enhanced CT as predictors of 14-day mortality and AKI within 7 days in septic shock. METHODS: 144 patients with septic shock and 60 negative cases were included. The vascular parameters from CT were measured and calculated, including aortic density in arterial (Den(a)-A) and venous phase (Den(a)-V), renal vein density in arterial (Den(rv)-A) and venous phase (Den(rv)-V), and renal vein-to-aortic density ratio in arterial (DenR(rv/a)-A) and venous phase (DenR(rv/a)-V). The parameters were compared between patients and controls, and between patients with different clinical outcomes, and assessed for predictive value of 14-day mortality and AKI within 7 days. RESULTS: Patients with septic shock presented significantly lower Den(rv)-A (p < 0.001) and DenR(rv/a)-A (p = 0.002) levels than the controls. In the septic shock group, patients who died had significantly lower Den(rv)-A (p = 0.001) and lower DenR(rv/a)-A (p < 0.001) than those who survived. Patients who developed AKI had significantly lower Den(rv)-A (p < 0.001) and DenR(rv/a)-A (p = 0.011) than those who did not. Multivariate analysis suggested DenR(rv/a)-A as an independent predictor of 14-day mortality (OR 0.012; 95% confidence interval [CI]:0.002,0.086; p < 0.001) and Den(rv)-A as an independent predictor of AKI (OR 0.989;95% CI:0.982,0.997; p = 0.006). CONCLUSION: In septic shock, significant decreases in Den(rv)-A and DenR(rv/a)-A were associated with the onset of AKI and predicted higher 14-day mortality. ADVANCES IN KNOWLEDGE: The renal vein density and renal vein-aortic density ratio in arterial phase of dual-phase contrast-enhanced CT may serve as good predictors of AKI and mortality in septic shock.