Timing in the absence of supraspinal input III: regularly spaced cutaneous stimulation prevents and reverses the spinal learning deficit produced by peripheral inflammation

In the absence of brain input, spinal systems can adapt to new environmental relations. For example, spinally transected rats given a legshock each time the leg is extended exhibit a progressive increase in flexion duration that minimizes net shock exposure, a simple form of instrumental learning. This capacity for learning is modulated by prior stimulation; both variable shock and inflammation produce a lasting inhibition of learning. An extended exposure to fixed spaced shock has no adverse effect on learning and opposes the consequences of variable shock. The present studies expand on these findings and demonstrate that fixed stimulation ameliorates the impact of peripheral inflammation. Spinally transected rats were administered 900 fixed spaced legshocks before (Experiment 1) or 1,800 legshocks after (Experiment 2) a subcutaneous hindpaw injection of capsaicin. Learning was assessed 24 hr later. Treatment with fixed shock attenuated the capsaicin-induced inhibition of learning. These findings suggest that fixed stimulation promotes adaptive plasticity and may foster recovery after injury.