Abstract
The IntelliCage is a home-cage-based radiofrequency identification (RFID) test system for studying learning behavior of group-housed mice. Specifically, the mice must learn where and how to get water within the IntelliCage. The protocol describes how to set up the IntelliCage, how to set up and start a learning experiment, what to consider before starting an experiment, and how to clean the system. © 2026 The Author(s). Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: General instructions for using the IntelliCage with mice Basic Protocol 2: IntelliCage cleaning.