Abstract
Chinese A drug vaccarin loaded polymer poly (vinyl alcohol) (PVA)-stilbazole quaternized (SbQ)/Zein was prepared in this study, using co-electrospun method. Then the morphologies and structures of PVA-SbQ/Zein composite nanofibers were observed by scanning electron microscope (SEM) and Fourier transform infrared spectrum (FTIR), respectively. Finally, biocompatibility of PVA-SbQ/Zein nanofibers with drug and without drug was evaluated. Results showed that vaccarin-loaded PVA-SbQ/Zein nanofibers had smooth surface and showed non-toxic to L929 cells. Drug vaccarin could promote cells attachment on nanofibers. The wound healing performance was examined in vivo by rat skin models and histological observations, and PVA-SbQ/Zein/vaccarin nanofibers showed better wound healing performance than petrolatum gauze group. 本文采用静电纺丝制备了负载王不留行黄酮苷的聚乙烯醇苯乙烯吡啶盐（PVA-SbQ）/玉米醇溶蛋白（Zein）纳米纤维，对纳米纤维的表面形貌和结构进行了观察，并对其进行了生物相容性评价。将负载王不留行黄酮苷的 PVA-SbQ/Zein 纳米纤维作为实验组，以凡士林纱布为对照组，建立小鼠皮肤损伤模型，对两种敷料在小鼠皮肤上的修复作用进行组织切片观察。实验结果表明，成功制备了负载王不留行黄酮苷的纳米纤维并呈现良好的形貌；负载黄酮苷的 PVA-SbQ/Zein 纳米纤维对 L929 细胞无毒害作用，且黄酮苷的存在可以促进细胞黏附生长。基于 PVA-SbQ/Zein/黄酮苷纳米纤维膜的创伤愈合材料对小鼠伤口愈合的效果要优于凡士林纱布。.