Abstract
Reduction of endogenous hydrogen sulfide (H(2)S) is considered to have an important impact on the progress of Parkinson's disease (PD), thus exogenous H(2)S supplementation is expected to become one of the key means to treat PD. However, at present, it is difficult for H(2)S donors to effectively penetrate the blood brain barrier (BBB), selectively release H(2)S in brain, and effectively target the mitochondria of neuron cells. Herein, we report a kind of nanomotor-based H(2)S donor, which is obtained by free radical polymerization reaction between l-cysteine derivative modified-polyethylene glycol (PEG-Cys) and 2-methacryloyloxyethyl phosphorylcholine (MPC). This kind of H(2)S donor can not only effectively break through BBB, but also be specifically catalyzed by cystathionine β-synthase (CBS) in neurons of PD site in brain and 3-mercaptopyruvate sulfurtransferase (3-MST) in mitochondria to produce H(2)S, endowing it with chemotaxis/motion ability. Moreover, the unique chemotaxis effect of nanomotor can realize the purpose of precisely targeting brain and the mitochondria of damaged neuron cytopathic diseases. This kind of nanomotor-based H(2)S donor is expected to enrich the current types of H(2)S donors and provide new ideas for the treatment of PD.