Abstract
The liver contains heterogeneous cell types that exhibit distinct spatial, molecular, and functional properties. The cells in the liver communicate with each other via a network of ligands and receptors and undergo cell type-specific transcriptomic reprogramming in disease. The advance of single-cell genomics has provided a powerful tool for unraveling the complexity of liver cells in health and disease with unprecedented resolution. In this review, we discuss insights gained from the recent single-cell RNA sequencing studies that shed new light on the molecular nature of liver cell heterogeneity, intercellular crosstalk, and disease-associated reprogramming.