Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection

Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan data (2010-2019), we found no difference in infection rates between those who received and those who did not receive antibiotics but a 3-fold increased risk of adverse events in those who did receive antibiotics.