Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

Moderna mRNA Beta/Omicron BA.1二价变异疫苗加强针两剂接种方案的随机临床试验免疫原性

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作者：Rouphael,Nadine G,Branche,Angela R,Diemert,David J,Falsey,Ann R,Losada,Cecilia,Baden,Lindsey R,Frey,Sharon E,Whitaker,Jennifer A,Little,Susan J,Kamidani,Satoshi,Walter,Emmanuel B,Novak,Richard M,Rupp,Richard,Jackson,Lisa A,Babu,Tara M,Kottkamp,Angelica C,Luetkemeyer,Anne F,Immergluck,Lilly C,Presti,Rachel M,Bäcker,Martín,Winokur,Patricia L,Mahgoub,Siham M,Goepfert,Paul A,Fusco,Dahlene N,Atmar,Robert L,Posavad,Christine M,Netzl,Antonia,Smith,Derek J,Telu,Kalyani,Mu,Jinjian,McQuarrie,Lisa J,Makowski,Mat,Makhene,Mamodikoe K,Crandon,Sonja,Montefiori,David C,Roberts,Paul C,Beigel,John H
期刊：Journal of Infectious Diseases影响因子：4.500
时间：2023起止号：2023 Dec 20;228(12):1662-1666
doi：10.1093/infdis/jiad323研究方向： 免疫/内分泌

Abstract

We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

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