Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis

利用药物水平检测和单基因组测序揭示暴露前预防期间人类免疫缺陷病毒血清转化的病例

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作者：Spinelli,Matthew A,Lowery,Brentton,Shuford,Jennifer A,Spindler,Jon,Kearney,Mary F,McFarlane,Jenny R,McDonald,Cheryl,Okochi,Hideaki,Phung,Nhi,Kuncze,Karen,Jee,Kathryn,Johannessen,DeeJay,Anderson,Peter L,Smith,Dawn K,Defechereux,Patricia,Grant,Robert M,Gandhi,Monica
期刊：Clinical Infectious Diseases影响因子：7.300
时间：2021起止号：2021 Jun 1;72(11):2025-2028
doi：10.1093/cid/ciaa1011

Abstract

Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.

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