Abstract
SIN3 (YOL004W) codes for a protein in Saccharomyces cerevisiae which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition, SIN3 has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of SIN3 in affecting mutation rates within the CAN1 reporter gene, suggesting an impact on genome stability.