The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH(3))(2)(phenanthridine)Cl]NO(3)

几何异构对单功能铂配合物反式-[Pt(NH(3))(2)(菲啶)Cl]NO(3)抗癌活性的影响

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Abstract

A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

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